Cytochromes P450: Drug Metabolism, Functions and Regulation :: Special Issue

Pharmaceutical Science and Technology

Special Issue

Cytochromes P450: Drug Metabolism, Functions and Regulation

Submission Deadline: 5 September 2023
Status: Submission Closed
Lead Guest Editor: Przemysław Jan Danek

About This Special Issue

Cytochrome P450 (CYP) is a superfamily of enzymes that function as monooxygenases and contain heme as a cofactor. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.

CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. This enzyme plays a key role in psychopharmacology. However, their role in the metabolism of endogenous substrates and new candidates for the future drugs is not completely understood. Hence, there is a need for further research to elucidate the mechanisms of CYP regulation and the molecular role of CYP in the metabolism of drugs, nutrients, xenobiotics, and endogenous compounds.

Original manuscripts and reviews dealing with the regulation and role of CYP enzymes in metabolism of xenobiotics or endobiotics are invited for consideration, for publication in Pharmaceutical Science and Technology.

List of Topics:

Cytochrome P450 (CYP)
Drug-Drug Interaction
Drug Metabolism
CYP Regulation
CYP Function
CYP expression

Lead Guest Editor

Przemysław Jan Danek

Department of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland

Guest Editors

Iwona Majcher-Maślanka

Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland
Anna Solarz

Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland
Renata Pukło

Department of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland
Ewa Bromek

Department of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland
Olga Pawełczyk

Department of Parasitology, Faculty of Pharmaceutical Sciences, Medical University of Silesia, Sosnowiec, Poland
Agnieszka Basińska-Ziobroń

Department of Pharmacokinetics and Drug Metabolism, Maj Institute of Pharmacology, Polish Academy of Sciensce, Kraków, Poland